Combining these medications may increase the risk of a rare but serious and potentially fatal condition that affects your muscles and kidneys
Abstract
It is a substrate for CYP3A4 and P-glycoprotein (P-gp), and concomitant administration with CYP3A4/P-gp inhibitors can cause life-threatening drug–drug
6/23 289568 Statins are among the most prescribed medications in the U
Colchicine can also produce myopathy, and rhabdomyolysis has been reported in severe cases
Drug Interactions between colchicine and simvastatin This report displays the potential drug interactions for the following 2 drugs: colchicine simvastatin Edit list (add/remove
Apart from transient early gastrointestinal intolerance in up to 6% of patients, long-term use of colchicine 0
There are 267 drugs known to interact with colchicine, along with 7 disease interactions, and 1 alcohol/food interaction
The interaction between colchicine and statins as well as colchicine and clarithromycin, can lead to colchicine toxicity which can cause rhabdomyolysis
Common simvastatin interactions include certain azole antifungals, antibiotics, and antivirals
Of the cytochrome P450 enzymes tested, CYP3A4 is the primary enzyme involved in the metabolism of colchicine
Future studies are warranted to validate clinically relevant risk factors that are strongly associated with the complications owing to the statin-colchicine The interaction between colchicine and statins is further complicated by the fact that both classes of drugs, independently, are recognized occasionally to cause muscle toxicity
Taking colchicine with certain medications raises your risk of side effects from colchicine
The safety meta-analysis involved 11,594 patients with coronary Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications
Statins are generally well tolerated with colchicine despite their own risk of musculoskeletal effects, although rhabdomyolysis has been reported with combination therapy
Blood dyscrasias, pre
It does not appear to impair CYP3A4 activity; thus, the DDI between colchicine and statins is Colchicine is a drug used to treat gout
An adverse interaction seems to be more common in those given colchicine long-term or at high-dose, or in those with renal impairment
But they may also prefer you take a different cholesterol medication and avoid this interaction altogether
St John's wort, a herbal remedy taken for depression, reduces the amount of atorvastatin in your blood, so it does not work as well
Adverse effects of statins include: Common or very common — asthenia, constipation, diarrhoea, dizziness, flatulence, gastrointestinal discomfort, headache, myalgia, nausea, sleep disorders, and thrombocytopenia
Manufacturer advises caution or monitor